Pravastatin is used to reduce an elevated cholesterol concentrations in the blood (lipid metabolism), if no sufficient lowering of cholesterol levels with a low-fat and low-cholesterol diet, a weight reduction and physical training.

Is this ingredient for what purposes?

  • Reduce cholesterol levels in the blood
  • Prevent arteriosclerosis
  • Reduce blood fat levels
  • After organ transplants reduce elevated blood lipid levels in response unterdrückenden measures
  • Reduce heart attack risks
  • Prevent recurrence of heart attacks
  • Reduce risk for stroke

So does Pravastatin

Learn more about the applications and the action of Pravastatin below. Read also the references to the statins, to which belongs the active ingredient Pravastatin drug group.

Application of the active substance: Pravastatin

Pravastatin is used to reduce an elevated cholesterol concentrations in the blood (lipid metabolism), if no sufficient lowering of cholesterol levels with a low-fat and low-cholesterol diet, a weight reduction and physical training.

The appropriate amount of active ingredients can range from a starting dose of 10 milligrams once a day up to a maximum dose of 40 mg. In order to strengthen the cholesterol-lowering effect of Pravastatin, the active substance can be combined with inhibitors of the bile acid recovery (Anionenaustauscherharze such as cholestyramine and colestipol). However, the Anionenaustauscherharze must at least four hours before or one hour after taking Pravastatin take place.

Furthermore, Pravastatin protects deposits of lime and lipids in the blood vessels and thus prevents arterial circulatory disorders. Especially the coronary vessels are sensitive to such deposits and subsequent inflammation. In patients with such changes in the coronary arteries (coronary artery disease) there may be a poor blood flow to the heart muscle (myocardial ischemia) with the feeling of angina (angina pectoris) up to the heart attack.

There is also an increased risk of poor circulation, which can manifest in the worst as stroke in the area of the brain. By Pravastatin can help prevent the initial occurrence of a stroke or a heart attack. Pravastatin can reduce the likelihood of the recurrence of a heart attack after an angina or a heart attack. Therefore Pravastatin is used in patients for a heart attack or a stroke, to reduce the risk. To do this, Pravastatin is taken once a day 40 milligrams. Pravastatin can occur even after an organ transplant used to reduce blood fat values, which are increased by the use of immune unterdrückenden drugs (immunosuppressive drugs). The initial dose is 20 milligrams of Pravastatin. The dose can be increased when more frequent medical supervision to 40 milligrams of Pravastatin.

Following applications of Pravastatin, in-depth information is available:

  • Lipid metabolism
  • Effect of Pravastatin

Pravastatin is one of the active group of statins. It causes the reduction of high cholesterol of levels in the blood, and thus prevents arteriosclerosis. Pravastatin also reduces the risk of heart attack and stroke.

Pravastatin causes a decrease of “bad” LDL cholesterol. The primary Angriffsort of the active substance is the liver. There, it inhibits an enzyme that is involved in the production of cholesterol. Pravastatin is eliminated for the most part of the liver in bile and the digestive tract and disposed of to a lesser extent through the kidneys into the urine.

The cholesterol-lowering effect occurs about two weeks after the start of therapy. Pravastatin is swallowed as a film-coated tablet. Taking regardless with some liquid meals.

Warnings and precautions

During the treatment, the liver function tests are medically to monitor. To reduce the dose of the drug or completely cancel the treatment is in improving the blood liver function tests on more than three times.

The muscle enzymes in the blood must be medically monitored during treatment. Increase muscle-specific blood values (creatine-kinase) by more than five times, the treatment should be terminated.

In pain, cramps, weakness, and special sensitivity of muscle, especially when they occur together with fever and general malaise, the doctor must be questioned immediately.

With breathing difficulties, cough reflex, fatigue, weight loss and fever, the treatment should be terminated.

Dizziness may occur during treatment with the drug.

Driving can be hazardous by the appearance of dizziness during the treatment.

Remedy ingredients sometimes trigger allergic reactions. Should you perceive signs of an allergic reaction, so you tell your doctor or pharmacist promptly.

What interactions shows Pravastatin?

It is important to note that the interactions can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

The simultaneous ingestion of Pravastatin and the immune unterdrückenden drug (immunosuppressants) Cyclosporine quadrupled the concentration of Pravastatin in the blood. As a result, severe cases of rhabdomyolysis muscle disease can occur. Coadministration of active substances is unavoidable, the Statin must be dosed weaker by the doctor.

The parallel use of Pravastatin and Fibrates (Gemfibrozil, Fenofibrate) or the vitamin Nicotinic Acid increases the risk of muscle disease and can be therefore not recommended.

The simultaneous ingestion of anion exchanger resins (cholestyramine and colestipol) leads to a reduced intake of Pravastatin, therefore Pravastatin should at least four hours, or one hour before taking the Anionenaustauscherharze to be.

With the simultaneous capture of Pravastatin and acid-binding agents (antacids), of Pravastatinspiegel in the blood by 35 percent decreases. Antacids should be taken therefore at least one hour before taking Pravastatin.


The following information about contra-indications for the purposes of Pravastatin in General, pregnancy & lactation, and in children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

When Pravastatin cannot use?

Pravastatin may not be applied in

  • Hypersensitivity to the active substance of Pravastatin
  • acute liver disease (hepatitis)
  • Permanent increases in liver-specific blood values (transaminases)
  • Diseases of the muscle with muscle fiber degradation
  • Boost skeletal muscle-specific blood values.

Extra medical care requires the use of Pravastatin in

  • Disorders of the liver
  • severe functional limitations of the kidney
  • Thyroid function
  • Alcohol abuse
  • Liver disease in the history of the patient

Patients with hereditary muscle diseases in the family.

Not recommended the use of Pravastatin in a special form of lipid disorders, namely the hereditary, so called homozygous familial hypercholesterolemia. For this clinical picture, no studies have been undertaken with Pravastatin.

What must you consider when pregnancy and breast-feeding?

The active ingredient of Pravastatin is not intended for use in pregnancy. There are no clinical data on a harmful for the unborn child. It is however conceivable that the cholesterol synthesis of the unborn is pulled affected by Pravastatin. In the event of pregnancy while taking Pravastatin, the drug should be discontinued immediately.

Pravastatin should be applied not in breastfeeding. It is known that Pravastatin passes into breast milk. If a therapy is absolutely necessary during lactation with Pravastatin should be breast-fed off previously.

What is taken into account in children?

The use of Pravastatin in children and adolescents is handled differently by the producers. Some indicate that the active substance should not be applied not in children and adolescents under the age of 18, others allow the gift from the age of eight. It is therefore in case of doubt consult the doctor.

What side effects can Pravastatin have?

Below, you will learn the most important thing possible, well-known side effects of Pravastatin. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

Common side effects: muscle spasms; Muscle pain; Joint pain.

Occasional or less common side effects: Fraud; Headache; Fatigue; Sleep disorders; Insomnia; Blurred vision; Diplopia; Heartburn (heartburn and esophageal inflammation;) Stomach problems (dyspepsia); Abdominal pain; Nausea and vomiting; Gas (flatulence); Diarrhea; Constipation (Obstipation); Problems with urination; night-time urination; Itching; Rash; Pustules; Hair loss; sexual restrictions.

Rare side effects: muscle weakness.

Very rare or occasional side effects: jaundice (jaundice); Inflammation of the liver; Leberzelluntergang (fulminant hepatic necrosis); Tendon irritation; Muscle decline with or without acute renal failure; dry skin; reduced appetite; Taste disorder; Hair loss; Cataract; Hypersensitivity reactions to Pravastatin with complaints such as skin rashes; Joint pain; Arthritis; Sensitivity to light; Changes in certain blood values (reduction of blood cells, boost the blood sedimentation rate); Possibility; depressive upsets (depression); Nerve disease; Hair loss; Erectile dysfunction; Sleep disorders.

Specialties: an adverse effect on the nerve seems all representatives of the statin drug group together, showing especially on the legs. The sign is numbness, burning sensations of the electron, or muscle spasms. When such symptoms, treatment with a Statin is to exit immediately. Diabetics are particularly at risk because the doctor often assigns the described symptoms of nerve damage by diabetes (diabetic neuropathy) and the offending Stastin is not used.

Further, all Statins common side effects such as memory loss, sexual disorders, depression and damage to the alveoli (interstitial lung disease), can occur even with Pravastatin.

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