Applications following, the suppositories for children / adults in conjunction with Novalgin, there is more detailed information:
- Pain (strong to very strong)
Novalgin suppositories for children / adults are available in the following variants:
|Pack size and dosage form||Potency (dosage per suppository||Cheapest price per Pack|
|5 Suppositories (Supposito-rien)||265,7 Metamizole milligrams||10,97 EUR alternatives|
|10 Suppositories (Supposito-rien)||885,68 Metamizole milligrams||12,98 EUR alternatives|
The following substance not effective components are part of the drug:
- Soy lecithin
Novalgin appears suppositories for children – adults
Novalgin suppositories for children / adults contain the active ingredient of Metamizole. Learn more about the applications and the action of Metamizole below. Read also the information about the groups of active ingredients to anti-inflammatory drugs, non-opioid pain relievers, among which the active ingredient of Metamizole. To note is also the special effect of Novalgin suppositories for children – adults
Fields of application of the active substance: Metamizole
Metamizole is rarely prescribed today due to the possible side-effects. However, the drug has very good antipyretic and analgesic properties, which is why it still is used in hospitals.
Metamizole is strong until very severe pain, for example, after surgery or injury, used in cancer pain or comparable serious pain conditions. High fever that does not speak to other measures, Metamizole is good effect.
The active ingredient is often used as reserve funds. This means that patients receive Metamizole, if other measures were not successful.
Following applications of Metamizole, in-depth information is available:
- Pain (strong to very strong)
Effect of Metamizole
Metamizole is one of the not acidic antipyretic analgesics from the Group of the non-opioid pain relievers. It is resistant to pain, calms and anti-spasmodic.
The mechanism of action for Metamizole is still not clear. It is assumed that Metamizole itself as well as its metabolite (4-N-Methylaminoantipyrin) on the central nervous system (spinal cord and brain) attack, but also in the other body tissues. Both seem to inhibit the pain mediation by prostaglandins. Prostaglandins are messengers involved in the sensation of pain. Thus, the effect of Metamizole and its main metabolite would be similar to those of the non-steroidal anti-inflammatory drugs.
Characteristics of the effect of Novalgin suppositories for children – adults
It has the formulation of suppositories. Suppositories are introduced into the bowel. There they dissolve, the active ingredients penetrate the intestinal wall and go directly into the bloodstream. So is bypassed in this formulation of the stomach. Suppositories are therefore particularly suitable for patients who have problems with the stomach.
The inclusion of active substances from the intestine is less fully than drugs that are swallowed. Therefore, drugs in suppository forms are always somewhat higher dosed as for example in tablets or capsules.
Notes to the dosage instructions on the packaging and in the patient information:
The medicine contains the active ingredient of Metamizole in the form of Metamizole sodium monohydrate. 265,7 Milligrams of Metamizole correspond to 300 milligrams of Metamizole sodium monohydrate. 885,68 Milligrams of Metamizole correspond to 1000 milligrams of Metamizole sodium monohydrate.
The cone is the low dosage of 300 milligrams of Metimazol sodium monohydrate per suppositories for children, determines the higher of 1000 milligrams sodium monohydrate of Metimazol for adults.
Warnings & precautions
At higher dose levels may be impaired responsiveness, by motoring and driving machinery dangerous. This is true especially in conjunction with alcohol.
The blood count should be controlled regularly by doctors during treatment with the drug to exclude an agranulocytosis.
It comes after the fever or subcutaneous bleeding, is to consult the treatment immediately to cancel and the doctor.
The drug is not suitable for people with allergies or patients with low blood pressure.
The suppositories may be stored not warmer than 30 degrees.
Suppositories to 300 milligrams of Metamizole sodium monohydrate are not suitable for children under four years of age.
Suppositories to 1000 milligrams of Metamizole sodium monohydrate are not suited for children and young people under 15 years of age.
The cones are not suited to patients with hypersensitivity to soy or peanut.
Medicines can cause allergic reactions. Evidence for this can be: redness, runny nose, itching, swelling of the mucous membrane, itching and redness of the eyes, narrowing of the Airways (asthma). In rare cases, there may be allergic shock with loss of consciousness.
Should you perceive signs of an allergic reaction, immediately inform a doctor.
What interactions of active substance of Metamizole in Novalgin suppositories for children / adults are known? It is important to note that the interactions can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).
The concentration of Cyclosporine in the blood, and thus the effectiveness of the drug can be reduced by concurrent treatment with Cyclosporine. Simultaneous use is therefore the blood Cyclosporine concentration medically to control.
Simultaneous use of Metamizole and the antipsychotic chlorpromazine, a severe drop in body temperature can occur.
For the Pyrazolone chemically related to Metamizole is known that enter into interactions with oral antidiabetic drugs, captopril (agents for reducing blood pressure), lithium (for depression), methotrexate (drug), and triamterene (Entwässerungsmittel). In addition, they evoke changes the effectiveness of other antihypertensive drugs and drainage equipment (except furosemide). Can show these interactions in Metamizole.
The dosage and the duration for the drug is set by the doctor depending on the strength of the pain or high fever. As General dosing guidelines can be considered:
Dosage of 300 mg suppositories
Children aged four to six (16 to 23 kg body weight) receive a suppository as a single dose and up to three suppositories (900 milligrams of Metamizole sodium monohydrate) daily maximum amount.
Children aged seven to nine (24 to 30 kg body weight) a suppository receive as single dose and up to four cones (1200 milligrams Metamizole sodium monohydrate) daily maximum amount.
Children aged ten to twelve (31 to 45 kg body weight) one or two suppositories given as single dose and up to five suppositories (1500 milligrams of Metamizole sodium monohydrate) daily maximum amount.
Young people aged 13 to 14 (46 to 53 kg body weight) take one or two suppositories as single dose and up to six suppositories (1800 milligrams Metamizole sodium monohydrate) daily maximum amount.
Doses of 1000 mg suppositories
Adults and adolescents over 15 years (about 53 kilogram of body weight) take a suppository as a single dose and up to four cones (4000 milligrams Metamizole sodium monohydrate) daily maximum amount.
The complaints within a half an hour should improve after the one-time use of the drug. This is not the case, the above each single dose throughout the day can be taken after consultation with the doctor distributed several times. The maximum daily doses are not to exceed and never at the same time it should be administered.
In older patients, impaired renal function or deterioration of general condition, the doctor must reduce the dose.
As possible after the defecation, insert the suppository by bowel movements.
The following information about contra-indications in the application suppositories of Novalgin for children / adults in General, pregnancy & lactation, and in children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).
When are Novalgin not allowed suppositories for children / adults?
Metamizole should not be used in
- Hypersensitivity to the active substance, as well as similar substances from chemical group of Pyrazolone or Pyrazolidine
- Bone marrow function disorders and diseases of the haematopoietic system
- Intolerance of other analgesics (non-opioid analgesics, non-steroidal painkillers) in the form of allergic reactions after use
- a genetically induced lack of a specific enzyme, the so called glucose-6-phosphate dehydrogenase (risk of anaemia due to destruction of blood cells)
- certain liver dysfunction (acute hepatic Porphyria).
The active ingredient may be prescribed only after careful medical risk benefit in
- induced allergic asthma bronchiale and chronic hives and intolerance reactions to dyes or alcohol
- Kidney and liver dysfunction
- high fever
- severe constriction of the coronary vessels, the vessels of the brain and heart attack
low blood pressure or cardiovascular unstable. Here, it can be a dangerous drop in blood pressure especially in the gift with the syringe. The single dose should not exceed 1 G Metamizole and must slowly be injected (maximum 0.5 grams per minute).
In patients older or with poor general condition, the doctor needs to select weaker doses.
What must you consider when pregnancy and breast-feeding?
So far, too few pregnant women were treated with Metamizole reliably assess the compatibility for mother and child. Metamizole can penetrate the placenta and reach the child. Although himself showed no damage to the unborn child in the Tierexperiment, the active ingredient in the first third of the pregnancy, not and the second should be applied only after strict medical risk benefit. Also in the last third of pregnancy, the use of Metamizole is prohibited. As all substances that inhibit the body’s production of prostaglandins, could the active ingredient to a blood, supply of the unborn and cause complications at birth due to blood clotting.
The metabolites of Metamizole are excreted into breast milk, therefore must be breastfed during treatment with the drug and at least up to 48 hours after its last application does not.
What is taken into account in children?
The restrictions on the use of Metamizole in children are specified differently by the producers for the different pharmaceutical forms. So, the restriction on the age, but also on body weight may require. There are always special for each drug warnings to note. But in General, the following guidelines apply:
Metamizole in tablet form is approved for the gift to children under ten years of age.
Cone-shaped the active ingredient in strength may only be taken 300 mg over four years to children in strength, 1000 mg at young people from 15 years.
The use of drops or injections of Metamizole are prohibited in newborns and infants under three months or five kilogram of body weight, as the compatibility of the active substance in this age group was not sufficiently investigated. The child to be treated is older than three months, an injection in the muscle tissue may be, an injection into the vein is prohibited.
What side effects can the active ingredient of Metamizole in Novalgin have suppositories for children / adults? The following, you learn the most important thing possible, well-known side effects of Metamizole in Novalgin suppositories for children / adults. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the drug form of the drug (for example, Tablet, syringe, ointment).
Uncommon side effects: allergic rash, low blood pressure.
Rare side effects: spotty pustel-rashes, white-blood-deficiency.
Very rare side effects: Schmerzmittel-asthma, severe skin reactions (Stevens-Johnson Syndrome, Lyell Syndrome), circulatory shock, lack of granulocytes, lack of platelets, deterioration of kidney function, protein in the urine, urinary excretion deficiencies, Harnsperre, inflammation of the blood vessels (for injection), emotional disorders (anxiety, agitation, delirium, depression, delusions, apathy).
Specialties: Vereinzelt particularly serious cases of skin reactions can occur such as the Toxic Epidermal Necrolysis (TEN). Called this also staphylogenes Lyell Syndrome cutaneous reaction leads to the large blasigen skin separation and is a severe, life-threatening disease.
During the application of Metamizole there may be agranulocytosis and lack of platelets to a life-threatening blood-formation disturbance, therefore the blood count should be controlled regularly by doctors. The patient gets fever after application of the active substance or he noticed subcutaneous bleeding, immediately discontinue treatment and the doctor is to ask.
When injections, pain in the injection site and local reactions at the injection site may occur in some cases. Also, there can be a strong drop in blood pressure in an injection into the veins in rare cases.