The following substance not effective components are part of the drug:

  • Benzyl alcohol
  • Sodium chloride
  • Sodium hydrogen phosphate
  • Sodium hydroxide (for pH adjustment)
  • Water f. inj.-purposes

Pro fact appears per injectione

Pro fact per injectione contains the active substance of Buserelin. Learn more about the applications and the action of Buserelin below. Read also the information about the active group of hypothalamic hormones, among which the active ingredient of Buserelin.

Drug Price per mg of the active substance Dosage of the active substance Packungs-size Cheapest price per Pack
Pro fact per injectione 7.42 EUR 1 mg per ml injection solution 11 ml injection solution Price 81,59 EUR (8.01 EUR), (0,00 EUR shipping) price comparison
Pro fact Depot 2 / 3 month implant 54,38 EUR 9,45 mg per prefilled syringe 2 Syringes Price 1027,85 EUR (10,00 EUR), (0,00 EUR shipping) price comparison
Pro fact Depot 2 / 3 month implant 54.89 EUR 9,45 mg per prefilled syringe 1 Prefilled syringe Price 518,72 EUR (10,00 EUR), (0,00 EUR shipping) price comparison
Pro fact Depot 2 / 3 month implant 61,57 EUR 6,3 mg per prefilled syringe 1 Prefilled syringe Price 387,90 EUR (10,00 EUR), (0,00 EUR shipping) price comparison

Application of the active substance: Buserelin

Buserelin is used for the treatment of hormone-dependent cancer of the prostate gland (prostate cancer). It prevents the production of the male hormone testosterone and stops the growth of tumor (malignant cancer) this in the long term.

Following applications of Buserelin, in-depth information is available:

  • Prostate cancer
  • Mode of action of Buserelin
  • Buserelin is among the Group of hypothalamic hormones and is a synthetically-produced hormone that is similar to a natural releasing hormone in the midbrain.

The drug causes the release of testosterone from the testicular cells first. In the long term but, by a feedback mechanism on the pituitary, it causes the inhibition of sex hormones. The sexual organs are no longer encouraged to produce testosterone. This caused a downtime of testosterone production in the long term. This responsive tissue is stimulated to testosterone no longer to grow. Prevent hormone-sensitive malignant Krebsgeschwulste (tumors) of the prostate gland (prostate) from so their growth, because of the Wachtumsanreiz on the tumor cells is turned off. The tumor is back as a result.

Warnings & precautions

The active ingredient can cause dizziness and thus the concentration and responsiveness affect. As a result, the ability to participate on the road and use machines can be reduced.

The effect of antidiabetic drugs can be toned down. It is advisable to control blood sugar levels in diabetics more frequently.

In patients with high blood pressure, the blood pressure should be controlled regularly.

Patients with depression should be regularly amended to investigate, because it might cause a deterioration or a recurrence of depression below the average.

Medicines can cause allergic reactions. Evidence for this can be: redness, runny nose, itching, swelling of the mucous membrane, itching and redness of the eyes, narrowing of the Airways (asthma). In rare cases, there may be allergic shock with loss of consciousness.

Should you perceive signs of an allergic reaction, immediately inform a doctor.


What interactions of Buserelin in fact pro active substance per injectione are known? It is important to note that the interactions can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

No studies on interactions have been carried out.


To initiate therapy, per fact is injected three times per day for seven days per 500 Μl per injectione under the skin.

The medicinal solution is available in two multiple-sampling bottles to each 5.5 milliliters. For each gift, taken with a scaled syringe 500 Μl from the bottle and it closed again.

On the eighth day after the start of treatment, therapy with a spray bottle for the nasal application will continue.


The following information about contra-indications for the purposes of Pro fact per injectione in General, pregnancy & lactation, and in children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

When Pro fact cannot use per injectione?

Buserelin may not be applied with hypersensitivity to the active substance or other LHRH analogues (hypothalamic hormones) and hormone resistance and after removal of the testicles.

What must you consider when pregnancy and breast-feeding?

The active ingredient is used only in men.

What is taken into account in children?

The drug is not approved for use in children.

Side effects

What side effects can the active ingredient of Buserelin in Pro fact per injectione have? Below, you will learn the most important thing possible, well-known side effects of Buserelin in Pro fact per injectione. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the drug form of the drug (for example, Tablet, syringe, ointment).

Common side effects: reduction of sexual desire, impotence, regression of testes, hot flashes, headaches.

Uncommon side effects: symptoms of hypersensitivity with redness, itching, rashes, breast education, slight change of the liver function tests, water retention in the legs, fatigue, constipation, drowsiness, dizziness.

Rare side effects: shortness of breath or shock, nervousness, depression, anxiety disorders, sleep disorders, memory problems, ear noise, Kribbeln feelings, visual disturbances, heart palpitations, change in blood pressure, nausea and vomiting, diarrhea, body aches, change of glucose tolerance.

Very rare side effects: benign tumors of the pituitary gland, decrease of white blood cells, sense of thirst, increase or decrease of appetite.

Specialties: At the beginning of the treatment side effects can occur through the release of testosterone such as bone pain by metastases (settlements of cancer cells), cancer pain, weakness of the legs, difficulty urinating, stowage of organism and blood clots (thrombosis).

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