Monoflam 50 mg / 100 mg suppositories

All fields of application by the manufacturer

Applications following, the 50 mg / 100 mg suppositories in conjunction with Monoflam, there are more detailed information:

  • Pain (mild to moderately strong)
  • Inflammation
  • Gout
  • Osteoarthritis
  • flammable rheumatic diseases

Drug overview

Monoflam 50 mg / 100 mg suppositories are available in following variants:

Pack size and dosage form Potency (dosage per suppository) Cheapest price per Pack
10 Suppositories (Supposito-rien) 46,54 Milligrams of diclofenac 10,61 EUR alternatives
10 Suppositories (Supposito-rien) 93,09 Milligrams of diclofenac 11.06 EUR alternatives
50 Suppositories (Supposito-rien) 93,09 Milligrams of diclofenac 20,27 EUR alternatives

Other components

The following substance not effective components are part of the drug:

  • Hartfett

So, Monoflam is 50 mg / 100 mg suppositories

Monoflam 50 mg / 100 mg suppositories contain the active ingredient diclofenac. Learn more about the applications and the action of diclofenac below. Read also the information about the groups of active ingredients to anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, to which belongs the active ingredient diclofenac. Please note, the special effect of Monoflam also is 50 mg / 100 mg suppositories

Fields of application of the active substance: diclofenac

The active ingredient diclofenac is used for the treatment of mild to moderately severe pain joint wear (arthrosis), migraine, headache and menstrual pain, and fever. This be taken up to 75 milligrams of the active substance per day. However, the use in fever should be no more than three days and in pain for no more than four days. Diclofenac dosages to take up to 25 milligrams per tablet or Dragee are prescription-free.

Higher dosages of the active substance be administered to reduce strong to very strong pain like in gout, fibromyalgia, flammable rheumatic diseases, diseases, or even cancer.

Diclofenac can be applied also in the form of eye drops for conjunctivitis and inflammation after eye surgery. In these cases, the active ingredient is used to relieve pain, inflammatory inhibition and the swelling. In addition diclofenac can occur during an operation on the eye used to avoid a narrow position of the pupil.

Externally, diclofenac cause the inhibition of inflammatory complaints by joint wear, with swelling and inflammation as a result of injury and rheumatic complaints of muscles, ligaments and tendons used. Actinic Keratoses are a special area of application for diclofenac, i.e. resulting keratinization disorders of the skin by sunlight. Actinic Keratoses are precursors of Stachelzell Hautkrebses.

In-depth information is available to the following application areas of diclofenac:

  • Pain (mild to moderately strong)
  • Inflammation
  • Gout
  • Osteoarthritis
  • flammable rheumatic diseases
  • Fibromyalgia
  • Pain (strong to very strong)
  • Deficiencies
  • Menstrual pain
  • Fever
  • Vein diseases
  • Migraine

Mode of action of diclofenac

A damage to body tissues due to injury, infection or inflammation produced so-called prostaglandins by Special enzymes, the Cyclooxigenasen. These prostaglandins strengthen the inflammatory reaction in the tissue and irritate the nerve endings in injured tissue as messengers. Prostaglandins also provide a transmission of pain signals to the brain, where the perception of pain and pain processing is done. Also in the brain, the prostaglandins attract the center of temperature control, which then leads to fever.

Diclofenac belongs to the drug group of non-steroidal anti-inflammatory drugs and the subgroup of acetic acid compounds. Like all non-steroidal anti-inflammatory drugs, recognises also the effect of diclofenac in the Cyclooxigenasen. By the active substance blocking these enzymes, it prevents the formation of prostaglandins. So, the prostaglandin-mediated pain and inflammatory reactions are suppressed. Diclofenac has anti-inflammatory, swelling off and analgesic. On the influence of the temperature control centre in the brain it is also an antipyretic effect.

Why it is effective to diclofenac in keratinisation disorders of the skin, could be clarified so far not fully. However, one also suspects a connection with the inhibition of the Cyclooxigenase.

Special features of the effect of Monoflam 50 mg / 100 mg suppositories

Suppositories are introduced into the bowel. There they dissolve, the active ingredients penetrate the intestinal wall and go directly into the bloodstream. So is bypassed in this formulation of the stomach. Suppositories are therefore particularly suitable for patients who have problems with the stomach.

The inclusion of active substances from the intestine is less fully than drugs that are swallowed. Therefore, active substances in forms of cone are dosed usually somewhat higher than for example in tablets or capsules. At same dosage, a slightly weaker effect arises opposite the dosage forms for taking.

Notes to the dosage instructions on the packaging and in the patient information:

The medicine contains the active ingredient diclofenac in the form of diclofenac sodium. 46,54 Milligrams of diclofenac correspond to 50 milligrams of diclofenac sodium. 93,09 Milligrams of diclofenac correspond to 100 milligrams of diclofenac sodium.

Warnings & precautions

The internal use of the drug may cause drowsiness and dizziness fatigue, that make dangerous driving and using machines.

Fever, bloody vomiting, Blutstuhl or bloody diarrhea during treatment a doctor is immediately to look for.

The daily dose of the drug should not exceed 150 milligrams for adults, because otherwise poisoning can occur.

Young people under 18 should be no more than 50 milligrams of the drug as a single dose.

Patients with hemorrhoids should take the drug not in suppository form.

Because the drug affected blood sugar levels, the dose of blood sugar lowering drugs must be adapted in diabetics may.

Long-term use of the drug in high doses, a kidney damage is possible.

Rhabdomyolysis prophylaxis requires regular medical monitoring of liver function tests, kidney function, and the doctors.

Prolonged use of the drug occur headache, which may be treated by increased doses.

When high blood pressure and/or complaints causing heart muscle weakness in prehistoric times, special medical surveillance is necessary because it is possible by the drug to water retention in the fabric.

The 100 mg suppositories are not suited to patients under 18 years of age.

The 50 mg suppositories are not for patients under the age of 15.

Medicines can cause allergic reactions. Evidence for this can be: redness, runny nose, itching, swelling of the mucous membrane, itching and redness of the eyes, narrowing of the Airways (asthma). In rare cases, there may be allergic shock with loss of consciousness.


What interactions of active substance of diclofenac in Monoflam are known 50 mg / 100 mg suppositories? It is important to note that the interactions can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

The simultaneous use of diclofenac and the cardiac Glycoside digoxin, lithium (for depression), rheumatism and cancer methotrexate or disambiguation phenytoin increases the concentration of those substances in the blood. There may be poisoning.

Their blutzuckerspiegel-reducing effect is increased with concurrent administration of funds to take against diabetes (oral antidiabetic drugs). It is recommended therefore a medical examination of the blood glucose levels. In diabetes patients, the dose of diabetes medicines may be adapted by the physician.

The simultaneous intake of potassium-dewatering equipment (diuretics) increases the risk of a high concentration of potassium in the blood resulting in possible cardiac arrhythmia.

Medium to high blood pressure (antihypertensives) and Entwässerungsmittel (diuretics) are weakened in their effect by diclofenac. From the Group of ACE inhibitor blood pressure senkern the risk of kidney damage increases at the same time.

Gichtmittel Probenecid and Sulfinpyrazone reduce the excretion of diclofenac and thus increase the risk of unwanted effects.

Also increased risk of side effects by taking glucocorticoids or other non-steroidal anti-inflammatory drugs, in particular the risk of stomach bleeding and-Geschwüren is increased.

Simultaneous use of diclofenac and anticoagulants, while heavy alcohol consumption, there is an increased risk of bleeding.

The kidney-damaging effect of ciclosporin (against the reaction of rejection after organ transplants) is reinforced by diclofenac.


Diclofenac is dosed by a doctor depending on the severity of the disease. In general the recommended dose range for adults and adolescents over 15 years lies between 50 and 150 milligrams of diclofenac sodium per day, spread over one or two Einzelgaben.

The cones are available in 50 and 100 milligrams of the active substance diclofenac sodium. Several lower-dose cones together can be used to get the desired dosage. Deep, insert the suppository in the anus. Be sure to empty the colon through bowel movements.

50 mg suppositories for adults and adolescents over 15 years can take one to three times a day a suppository.

Once a day, 100 mg suppositories adult over 18 years can apply a suppository. If the daily dose can be increased by additional gift of a tablet containing 50 mg active substance on 150 milligrams of diclofenac sodium.

150 Milligrams of diclofenac sodium represent the maximum daily maximum amount.

The duration of treatment determined by the attending physician. For rheumatic diseases, the application over a longer period may be necessary.


The following information about contra-indications in the application of 50 mg / 100 mg suppository in General, pregnancy & lactation, and children of Monoflam. It is important to note that the contra-indications can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

When are Monoflam not allowed 50 mg / 100 mg suppositories?

Diclofenac may not be administered in

  • Hypersensitivity (allergy) to the active substance
  • Patients who respond to the use of similarly acting drugs (such as aspirin or other non-steroidal anti-inflammatory drugs) – seizures, narrowing of Airways (bronchospasm), acute coryza (rhinitis) or red, itchy rashes (urticaria) with asthma
  • Stomach or intestines
  • Education of blood disorders, blood coagulation disorders
  • Stomach and intestines
  • severe heart muscle weakness
  • acute bleeding.

Diclofenac should be applied generally only under strict medical assessment of the risk-benefit for asthma, hay fever, General allergy addiction, nasal and chronic respiratory infections. An internal application should be medically monitored at:

  • acute metabolic disorders (Porphyria) and liver dysfunction
  • Skin diseases by a disturbed immune system such as Systemic Lupus Erythematosus (SLE), as well as mixed kollagenosen
  • Stomach problems or inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis
  • High blood pressure and/or heart muscle weakness
  • Patients immediately after a major operation
  • Coagulation defect or use of anticoagulants
  • older people
  • Renal impairment and intake of drainage products.

Suppositories with diclofenac düfen are applied not in colitis. Ointments and gels with diclofenac may be used with skin infections or skin inflammations, but only to intact skin.

What must you consider when pregnancy and breast-feeding?

Although the risk of malformations in the first taking diclofenac is low estimate of six months of pregnancy, but should pregnant women apply only the active substance, if the doctor considers it necessary.

In the last third of pregnancy, the use of diclofenac is prohibited. Diclofenac may prevent the contractions and delay the birth. In addition, the unborn child can carry of heavy damage.

Diclofenac and its degradation products pass over into breast milk. A use of the active substance during breastfeeding should be avoided.

What is taken into account in children?

Most manufacturers recommend that children and young people under 14 years of age should be no diclofenac, because no sufficient experience for the application exist in this patient population.

In some cases, a use of the active substance from the age of six is approved at appropriate dosage.

Before you can use in children and adolescents, therefore the limitations of the manufacturer or a doctor or pharmacist to note are to consult.

Side effects

What side effects can the active ingredient diclofenac in Monoflam have 50 mg / 100 mg suppositories? Below, you will learn the most important thing possible, well-known side effects of diclofenac in Monoflam 50 mg / 100 mg suppositories. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the drug form of the drug (for example, Tablet, syringe, ointment).

Free for sale, low doses of common side effects: arousal, fatigue, dizziness, nausea and vomiting, diarrhea, indigestion, headache, Bauchschmerz, flatulence, loss of appetite, transaminases – boost, skin rash.

Rare side effects: has, allergic reaction (including hypotension and shock), drowsiness, asthma (including shortness of breath), gastritis, gastro intestinal bleeding, hematemesis, bloody diarrhea, tar Chair, stomach intestine ulcers (with or without bleeding without breakthroughs), inflammation of the liver, jaundice, hepatic, hives, water retention in the tissue.

Very rare side effects: lack of platelets, white blood cell deficiency, anaemia (including hämolytischer anaemia, aplastic anemia), granulocytes – the absence, angioneurotic oedema (including swelling of the face), disorientation, depression, insomnia, nightmares, irritability, psychosis, sensation disorders, memory problems, seizures, anxiety, tremors, non-infectious encephalitis, taste disorders, stroke, Sehstörung, blurred vision, diplopia, ringing in the ears, hearing disorders, palpitations, chest pain, heart muscle weakness, heart attack, high blood pressure, inflammation of the blood vessels, pneumonia, colitis (including bloody colitis and exacerbation of a chronic inflammatory bowel disease) constipation, inflammation of the mucous membrane of the mouth, tongue inflammation,. Esophageal complaints, Darmverengungen, pancreatitis, severe liver inflammation, rash (including Stevens-Johnson Syndrome, Lyell Syndrome, blisters, dermatitis exfoliativa), redness (multiforme including erythema), hair loss, hypersensitivity to light, subcutaneous bleeding (also allergic), itching, acute renal failure, Bluturin, urine protein, nephrotic syndrome, Nierenkörperchenentzündung, papilla necrosis, worsening infection-induced inflammation (for example, development of a tissue destructive inflammation of the muscle).

Higher, prescription dosage of common side effects: nausea and vomiting, diarrhea, slight bleeding in the gastrointestinal tract (this sometimes anaemia.) When applied to the skin: Skin redness, itching, burning, skin rash with Pustel-or hives.

Uncommon side effects: stomach ulcers, indigestion (dyspepsia), bloating, abdominal cramps, loss of appetite, headache, arousal, irritability, fatigue, drowsiness, dizziness, increase the liver enzyme values, hypersensitivity reactions as rash and itching. In suppositories: Local irritation, bloody mucus secretions, or painful bowel movements. When applied to the skin: Hypersensitivity reactions, contact dermatitis.

Rare side effects: Blutiges vomiting, Blutstuhl, bloody diarrhea, liver damage, anemia, errors of blood formation with Blutzellverlusten, hives, alopecia, water retention in the arms and legs.

Very rare side effects: inflammation of the mucous membrane of the mouth (stomatitis), inflammation of the tongue (Glossitis), injury of the esophagus, abdominal cramps, bleeding Dickdarmentzündungen, worsening inflammatory bowel diseases such as Crohn’s disease or ulcerative of colitis, constipation, Darmverengungen, Tastsinn disorders, taste sensory disorders, vision problems, ringing in the ears, hearing disorders, memory problems, disorientation, anxiety disorders, nightmares, tremors, depression, symptoms of meningitis (aseptic meningitis) such as neck stiffness, headache, nausea, vomiting, fever or Bewusstseinstrübung, kidney damage, kidney infections, inflammation of the pancreas, heart palpitations, chest pain, high blood pressure, heart muscle weakness, inflammation of the blood vessels (Vasculitis) or certain forms of pneumonia, Rash with blisters, eczema, redness, light sensitivity, subcutaneous bleeding including allergic forms, severe skin reactions (Stevens-Johnson Syndrome, Lyell Syndrome, General skin blush).

Specialties: During treatment with diclofenac severe hypersensitivity reactions can occur heart palpitations, blood pressure up to the menacing shock such as swelling of the face, tongue and larynx with narrowing of the Airways, shortness of breath and asthma attack. Asthma attacks taking diclofenac may occur even in people who otherwise suffer not asthma. The danger in eczema – and hay fever patients is especially great.

When using an active ingredient diclofenac patch, it can often come to redness, itching or allergic skin reactions.

When an injection into the muscle, there may be a burning sensation at the injection site. Also sterile abscesses, so-called fat tissue necrosis can occur when incorrect injection.

In recent studies, it was found that taking high doses of diclofenac may lead to an increased heart attack risk. Especially in already cardiac patients, the drug should be dosed therefore carefully.

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