Indomethacin is used mostly for pain due to joint diseases. The pain, which covers indomethacin here, range from mild to moderately severe pain or of strong to very severe pain. The active ingredient can combat the inflammation such as also the pain at the same time effectively.

Is this ingredient for what purposes?

  • Inhibit inflammation
  • Pain in joint diseases
  • Treat gout
  • Alleviating inflammation in ankylosing spondylitis
  • Reduce flammable conditional pain in rheumatic complaints
  • Treat painful swelling and inflammation after injuries and operations
  • After surgery alleviate inflammation of the eyes
  • Relieve pain (mild to moderately strong)
  • Relieve pain (highly until very strong)
  • Relieve menstrual pain
  • relieve flammable rheumatic diseases
  • Relieve pain in Fibromyalgia
  • Pain gout and osteoarthritis
  • Handle extra-articular rheumatism.

Indomethacin appears

Learn more about the applications and the action of indomethacin below. Read also the information about the drug group non-steroidal anti-inflammatory drugs, to which belongs the active ingredient indomethacin.

Fields of application of the active substance: indomethacin

Indomethacin is used mostly for pain due to joint diseases. The pain, which covers indomethacin here, range from mild to moderately severe pain or of strong to very severe pain. The active ingredient can combat the inflammation such as also the pain at the same time effectively.

Disorders where indomethacin is used, are gout, ankylosing spondylitis, rheumatoid arthritis, fibromyalgia, osteoarthritis, extra-articular rheumatism and other inflammatory rheumatic diseases and menstrual pain.

In addition, the active substance for the treatment of painful swelling and inflammation is suitable after injuries and operations.

On the eye, indomethacin is used to treat inflammation of the front section of the eye after surgery. During an operation on the eye, indomethacin prevents the narrow position of the pupil.

The active ingredient is in the form of tablets, capsules, and eye drops, as well as gel, spray, solutions or cones available.

Following applications of indomethacin, in-depth information is available:

  • Inflammation
  • Gout
  • flammable rheumatic diseases
  • Pain (mild to moderately strong)
  • Osteoarthritis
  • Fibromyalgia
  • Pink eye
  • Menstrual pain
  • Pain (strong to very strong)

Mode of action of indomethacin

Indomethacin works like the other nonsteroidal anti-inflammatory drugs from subgroup of acetic acid compounds.

When the pain was built, messengers, the prostaglandins are released, which irritate the nerve endings send pain signals to the brain. The perception of pain and pain modulation occurs in the brain.

Indomethacin inhibits the production of prostaglandins and relieve the pain and inflammation. It has anti-inflammatory, swelling off and analgesic. On the influence of the temperature control centre in the brain it is also an antipyretic effect.

Warnings and precautions

The liver and kidney values must be inspected regularly by doctors during treatment.

The blood must be examined regularly during the treatment by the doctor on formation of blood disorders.

Fever, sore throat, superficial wounds in the mouth, flu-like complaints, malaise, nose bleeding, skin bleeding, swelling of the face, swelling of the tongue, narrowing of the Airways, shortness of breath or Herzjagen a doctor must be sought immediately.

During long-term therapy, the patient should be examined regularly by the ophthalmologist.

Blurred vision occurs during treatment with the drug, the doctor must be visited.

At signs of infection or worsening an infection druch the medication a doctor must be sought.

Prolonged use of the drug occur headache, which may be treated by increased doses.

High blood pressure and/or mild to moderately severe heart muscle weakness in prehistoric times a regular medical monitoring is necessary because the drug can cause water retention in the tissue.

The response can be affected by the ingestion of the drug.

Remedy ingredients sometimes trigger allergic reactions. Should you perceive signs of an allergic reaction, so you tell your doctor or pharmacist promptly.

What interactions shows indomethacin?

It is important to note that the interactions can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

The simultaneous ingestion of indomethacin and digoxin, lithium, methotrexate, or phenytoin increases the concentration of those substances in the blood. There may be poisoning.

Their blutzuckerspiegel-reducing effect is increased with concurrent administration of funds against diabetes (oral antidiabetic drugs). It is recommended therefore a medical examination of the blood glucose levels. In diabetics, the dosage of antidiabetic drugs must be may be adapted by the physician.

The simultaneous intake of potassium-dewatering equipment (diuretics) increases the risk of a high concentration of potassium in the blood.

Medium to high blood pressure (antihypertensives) and Entwässerungsmittel (diuretics) are weakened in their effect by indomethacin.

Indomethacin can mitigate the effect of ACE inhibitors, at the same time increases the risk of kidney damage.

Probenecid and Sulfinpyrazone reduce the excretion of indomethacin and thus increase the risk of unwanted effects.

Also increased due to the intake of other nonsteroidal anti-inflammatory drugs (including the so-called Coxibe or Selective COX 2 inhibitors) or of glucocorticoids, the risk of side effects, particularly the risk of stomach bleeding and-Geschwüren is increased. The combination of these active ingredients is therefore to avoid.

Simultaneous use of indomethacin and anticoagulants, there is an increased risk of bleeding.

The kidney-damaging effect of Cyclosporine is reinforced by indomethacin.

In combination with acetylsalicylic acid, the effect can be mitigated by indomethacin, while its effect decreases with concurrent administration of phenobarbital.


The following information about contra-indications in the application of indomethacin in General, pregnancy & lactation, and in children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

When indomethacin cannot use?

Indomethacin may be administered not by hypersensitivity (allergy) to the active substance.

Also, patients who respond to the use of similarly acting drugs (such as aspirin or other non-steroidal anti-inflammatory drugs) – seizures, narrowing of Airways (bronchospasm), acute coryza (rhinitis) or red, itchy rashes (urticaria) with asthma, must not occupy the active substance.

Patients who have an increased bleeding tendency should be no indomethacin, because it affects blood clotting. This affects such patients who have suffered a stroke or a heart attack, and a now blood-thinning agents. Also patients with Blutbildungs-or blood coagulation disorders should apply indomethacin without medical advice.

People with a severe heart muscle weakness may not take indomethacin.

Indomethacin can cause even stomach and bowels. Patients with gastro intestinal ulcers in the history or stomach problems, inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis should be the active substance only after careful risk benefit by the physician.

People with asthma may apply only under regular medical supervision bronchial asthma, hay fever (allergy), nasal, or chronic respiratory infections indomethacin.

Also, patients with a light to medium-heavy heart muscle weakness (heart failure), acute metabolic disorders such as hepatic Porphyria, hepatic or high blood pressure should consult before applying with their doctor. This concerns also the elderly, children, alcoholics, and patients with certain immune diseases of like Systemic Lupus Erythematosus or mixed kollagenosen.

There may be a deterioration of renal function by indomethacin in patients with renal impairment (renal insufficiency). A special medical examination is needed here.

Indomethacin may be taken only with particular medical care immediately after major surgery.

What must you consider when pregnancy and breast-feeding?

Indomethacin should not be used during pregnancy and while breastfeeding.

What is taken into account in children?

Indomethacin should be applied in children only on medical advice.

What side effects can indomethacin have?

Below, you will learn the most important thing possible, well-known side effects of indomethacin. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

Common side effects: nausea and vomiting, diarrhea, slight bleeding in the gastrointestinal tract, headache, drowsiness.

Uncommon side effects: stomach ulcers, indigestion (dyspepsia), bloating, abdominal cramps, loss of appetite, arousal, irritability, fatigue, dizziness, increase of liver enzymes, drowsiness, slight fatigue, exhaustion, depression, itching, rash, ringing in the ears.

Rare side effects: Blutiges vomiting, Blutstuhl, bloody diarrhea, liver damage, anemia, Blutzellverluste, confusion, anxiety disorders, mental disorders, insomnia, nerve damage, muscle weakness, cramps, sensation disorders, transient loss of consciousness, coma, hives, hair loss, liver damage, formation of blood disorders such as reduction of white blood cells (leukopenia), agranulocytosis, reduction of red blood cells (anemia), reduction of blood platelets (thrombocytopenia), water retention, diplopia, deafness.

Very rare and occasionally occurring side effects: inflammation of the mucous membrane of the mouth (stomatitis), inflammation of the tongue (Glossitis), injury of the esophagus, abdominal cramps, bleeding Dickdarmentzündungen, worsening inflammatory bowel diseases such as Crohn’s disease or ulcerative of colitis, constipation, Darmverengungen, hearing disorders, memory problems, disorientation, nightmares, tremors, depression, skin rash with blisters, redness, hypersensitivity to light, small fleckige skin bleeding, allergic skin reactions such as redness (erythema), itching (pruritus), hives (urticaria), petechiae Exantheme or Erythromelalgia), severe cases of skin reactions such as Stevens-Johnson Syndrome or Lyell’s syndrome), Renal impairment, protein or blood in the urine, kidney damage, inflammation of the pancreatic, heart palpitations, chest pain, high blood pressure, heart muscle weakness, inflammation of the blood vessels (Vasculitis), certain forms of pneumonia (Pneumonitis), Überzuckerung, sugar in the urine, vaginal bleeding, deterioration of inflammation, severe hypersensitivity reactions such as swelling of the face, swelling of the tongue, inner throat swelling with narrowing of the Airways, shortness of breath to the asthma attack, symptoms of meningitis (aseptic meningitis) such as neck stiffness, headache, nausea, vomiting, fever, or Bewusstseinstrübung.

Specialties: A strengthening of the symptoms of epilepsy, Parkinson’s disease and psychiatric conditions is possible by indomethacin. Depending on the severity of the types a dose reduction or a discontinuation of therapy may be necessary.

In older patients, indomethacin can more often lead to adverse effects in the digestive tract, mainly to bleeding and breakthroughs that can also fatal.

In the course of a long term treatment with indomethacin, discoloration or cloudiness of the retina or cornea in the eye may occur in rare cases.

If newly occur during the use of indomethacin signs of infection or deteriorate, it is recommended the patient to consult the doctor immediately.

When an injection into the muscle, there may be a burning sensation at the injection site. Also sterile abscesses, so-called fat tissue necrosis can occur when incorrect injection.

Indomethacin slightly increases the risk for heart attack or stroke. This risk is more likely, is the higher the dose and the longer the treatment lasts. Not to exceed the recommended dose or duration of treatment. All side effects decrease, if the lowest effective dose over the shortest possible period of time will be applied.

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