Chloraldurat 500

All fields of application by the manufacturer

To this, with Chloraldurat 500 combined application area there is in-depth information:

  • Sleep disorders

Drug overview

Chloraldurat 500 is available in the following variants:

Pack size and dosage form Potency (dosage per capsule) Cheapest price per Pack
15 Capsules 500 Milligrams of chloral hydrate 12,99 EUR
30 Capsules 500 Milligrams of chloral hydrate 9.39 EUR (5.00 EUR), price (3,95 EUR shipping) price comparison

Other components

The following substance not effective components are part of the drug:

  • Eisen(II,_III) oxide (E 172)
  • Gelatine
  • Glycerol 85%
  • MACROGOL 400
  • Mannitol sorbitol Sorbitan higher polyols mixture (20-30%, 0-6% / 25-40% / 12.5-19%)-Trockensubstanz
  • Ponceau 4 R (E 124)
  • Titanium dioxide (E 171)

So does Chloraldurat 500

Chloraldurat 500 contains the active substance chloral hydrate. Learn more about the applications and the action of chloral hydrate below. Read also the information about the drug group sleep aid, to which belongs the drug chloral hydrate.

Application of the active substance: chloral hydrate

Chloral hydrate is used for sleep disorders, which can be eliminated by changes in behaviour and are caused by other underlying diseases or complaints.

It also serves to calm for excitation of physical and/or psychological origin such as Hirnorganisches psycho syndrome (HOPS).

In-depth information is available to the following application areas of chloral hydrate:

  • Sleep disorders

Effect of chloral hydrate

The effect of Schlafmittels chloral hydrate is based on a screening of the brain before stimuli. The Hauptwirkort of the active substance is the cerebral cortex. The exact mechanism of action is not yet sufficiently understood. It could be caused by a decreased production of special messengers (the hormone acetylcholine or GABA) and a reduction in their activity.

The Centre of sleep control in the area of interim and midbrain seems to remain unaffected. Therefore, the sleeping rhythms with the stages of sleep and the dream-rich REM-Phasen does not change.

Areas of application according to the manufacturer’s specifications

  • Sleep disorders
  • to reassure excitation of organic and/or psychological cause, such as for example when often due to a brain injury

Warnings & precautions

The ability to actively participate on the road and use machines is affected by the drug. This applies to the greater extent after insufficient sleep or in conjunction with alcohol.

The response can be affected by treatment with the drug. This applies to the greater extent after insufficient sleep or in conjunction with alcohol.

Should drink no alcohol during treatment with the drug.

Medicines can cause allergic reactions. Evidence for this can be: redness, runny nose, itching, swelling of the mucous membrane, itching and redness of the eyes, narrowing of the Airways (asthma). In rare cases, there may be allergic shock with loss of consciousness.


Chloral hydrate in Chloraldurat 500 is aware of the interactions of the active substance? It is important to note that the interactions can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

The sleep-promoting, soothing effect of chloral hydrate is reinforced by other Central-absorbing agents (such as other sleep medications) and alcohol.

The simultaneous application with oral anticoagulants such as coumarin, whose blood thinning effect can be strengthened or weakened.

The concomitant use of drugs that also prolong the QT interval in ECG (for example, antiarrhythmics of Class IA or III, antibiotics, means against malaria, H1 antihistamines, Neuroleptics) can lead to cardiac arrhythmia.

To avoid substances that lead to a low potassium levels in the blood (for example, certain Entwässerungsmittel).

Simultaneous use of furosemide and chloral hydrate, it can cause vasodilation, discomfort, redness (flush), blood pressure, and sweating.

Chloral hydrate may affect the results of the test for glucose in the urine and the Porter silver color reaction.


The capsules should be taken half an hour before going to sleep whole with plenty of liquid. Lighter taking to make glide-enabled the capsules, you can dive shortly before them in lukewarm water. The doctor decides on the duration of the application.

One or two capsules are taken to the General sleep therapy. May in adults the maximum daily dose of two grams chloral hydrate (equivalent to four capsules) are not exceeded.

Children get for sleep disturbances 50 milligrams of chloral hydrate per kilogram of body weight (equivalent to weighing 30 kilograms of three capsules) and in unrest and excitation 25 milligrams per kilogram of body weight (equivalent to a weight of 30 kg 1.5 capsules). The daily intake should, if possible, be distributed to three or four doses. A single dose should not exceed two capsules.

A termination of treatment with Chloraldurat 500 should be by weekly halving of the dose gradually.


The following information on contra-indications for the purposes of Chloraldurat 500 in General, pregnancy & lactation, and children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of the drug (for example, Tablet, syringe, ointment).

When Chloraldurat 500 cannot use?

Intolerance against the active substance or of allergy to other sedative (of aldehyde type) chloral hydrate may not be a.

Serious liver and kidney damage, severe cardiac and circulatory weakness and during treatment with anticoagulants such as coumarin chloral hydrate may not be used. Similarly, an existing stomach lining inflammation (gastritis), respiratory distress and a sleep apnea syndrome exclude treatment with chloral hydrate.

Must take the active substance only with particular care patients with low potassium levels, slow heart beat, congenital long QT syndrome (striking changes in the ECG), and other heart disorders (especially arrhythmia).

What must you consider when pregnancy and breast-feeding?

Chloral hydrate should not be used in pregnancy and lactation.

What is taken into account in children?

The use of chloral hydrate is not allowed for children under six years of age.

Side effects

What side effects can the drug chloral hydrate in Chloraldurat 500 have? Below, you will learn the most important thing possible, well-known side effects of chloral hydrate in Chloraldurat 500. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the drug form of the drug (for example, Tablet, syringe, ointment).

Common side effects: drowsiness, dizziness, headache, “paradoxical” reactions (increased activity), mild respiratory depression, disorientation, confusional, anxiety, dizziness, insomnia, fatigue (hangover) morning after application for sleep disturbances. These reactions are known as paradoxical because the drug as a sleep aid should have actually opposite effects.

Uncommon side effects: allergic reactions, skin redness.

Rare side effects: irritation of the mucous membrane (with rektaler application), slowing down the heartbeat, increase of Leberwerten (hepatic transaminase), occurrence of ketone bodies in the blood, waste of a clotting in the blood (Hypoprothrombinämie), arrhythmia (can prolong the QT interval in ECG).

Very rare or occasional side effects: discomfort in the gastro-intestinal area, bloating, feeling of pressure, nausea, diarrhea.

Specialties: In the handling of new-born children an increase of bilirubin cannot be ruled out.

For longer lasting use a habituation is and in some cases also a dependency cannot be ruled out. It occurs but to a lesser extent than with other pills.

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