Clopidogrel

Clopidogrel is used especially in patients, which reduce blood clotting (colloquially: “Dilution of the blood”) is desired. This is the case for example after a stroke or a heart attack to reduce the risk of recurrence. Recent studies have shown however no special advantage of clopidogrel to the active substance acetylsalicylic acid is also used for this type of application.

Is this ingredient for what purposes?

  • Prevent heart attack or stroke
  • Reduce blood clotting
  • Prevent blood clots
  • Inhibit the platelets together storage

Price comparison

The table below shows all collected medication containing the active ingredient of clopidogrel:

Drug Price per 10 mg of the active substance Dosage of the active substance Packungs-size and dosage form Cheapest price per Pack
Iscover 75 mg / – 300 mg film tablets 0.35 EUR 300 mg per film Tablet 30 Film tablets Price 317,31 EUR (10,00 EUR), (0,00 EUR shipping) price comparison
Iscover 75 mg / – 300 mg film tablets 0.35 EUR 75 mg per film Tablet 100 Film tablets Price 266,05 EUR (10,00 EUR), (0,00 EUR shipping) price comparison
Plavix 75 mg film tablets 0.37EUR 75 mg per film Tablet 100 Film tablets Price 277,58 EUR (10,00 EUR), (0,00 EUR shipping) price comparison
Iscover 75 mg / – 300 mg film tablets 0.39 EUR 75 mg per film Tablet 28 Film tablets Price 81,43 (7.88 EUR), EUR (0,00 EUR shipping) price comparison
Plavix 75 mg film tablets 0.40 EUR 75 mg per film Tablet 28 Film tablets Price 84,67 EUR (8,20 EUR), (0,00 EUR shipping) price comparison

How Clopidogrel works

Learn more about the applications and the action of clopidogrel below. Read also the information about the active group of antiplatelet, among which the active ingredient clopidogrel.

Fields of application of the active substance: Clopidogrel

Clopidogrel is used especially in patients, which reduce blood clotting (colloquially: “Dilution of the blood”) is desired. This is the case for example after a stroke or a heart attack to reduce the risk of recurrence. Recent studies have shown however no special advantage of clopidogrel to the active substance acetylsalicylic acid is also used for this type of application.

Patients with an unstable angina pectoris, also so get Clopidogrel with deposits in the blood vessels of the heart. This is to prevent that blood aggregation form, which can clog then important vessels. For the same reason, get patients with so-called peripheral arterial Occlusive Disease, which also deposits in blood vessels of extremities are present, this active substance.

Clopidogrel is sometimes combined with acetylsalicylic acid, in order to strengthen the effect of blood as yet.

In-depth information is available to the following fields of application of clopidogrel:

  • Stroke
  • Heart attack
  • Angina pectoris
  • Heart and cardiovascular problems
  • Arterial Circulatory Disorders

Mode of action of clopidogrel

The active ingredient of clopidogrel belongs to the Group of antiplatelet. Like all active substances of this group serves also Clopidogrel of the reduction in blood clotting. Thus, a Verklumpung of blood should be avoided and prevent strokes and heart attacks.

Tissue is injured in the human body, cells are destroyed it. These cells release their contents into the environment as a result. Be destroyed cells that line a blood vessel, including adenosine diphosphate (ADP) is released. This ADP can cause these together storage when it encounters blood platelets (thrombocytes). It forms a clumping of platelets (speaking of platelet aggregation), which is able to close the hole in the vessel wall. So, ADP is an impetus that blood aggregation can make.

There are diseases where such a blood Verklumpung represents a danger for the patient. Clopidogrel helps prevent the combined storage of blood platelets by it blocked the attack on the platelet ADP. As a result the ADP can not affect the platelets and reduces blood clotting. Colloquially, it is said the blood is “diluted”. The most dangerous side effects of this substance are haemorrhage, who can be breastfed is difficult due to the impaired function of platelets.

Warnings and precautions

Any observed bleeding must be communicated to the attending physician.

Signs of liver damage such as weight gain by water retention in the abdominal cavity, itching, nausea, confusion, or jaundice, occurs during the treatment with the drug a doctor immediately is to communicate.

Seven days prior to surgery the drug must be removed.

Patients with gastric or intestinal must be monitored carefully by doctors during treatment with the drug.

Anemia, nervous deficit or fever occur in the treatment, a doctor is immediately to communicate.

The combination of the drug with interactions (to reduce the gastric acid distribution) must be avoided. Instead, the doctor can prescribe the drug ranitidine.

Remedy ingredients sometimes trigger allergic reactions. Should you perceive signs of an allergic reaction, so you tell your doctor or pharmacist promptly.

What interactions shows Clopidogrel?

It is important to note that the interactions can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

As a precaution, Clopidogrel should be ingested by means of other, affecting blood clotting. These include: warfarin, abciximab, eptifibatide and other glycoprotein IIb/IIIa inhibitors, acetylsalicylic acid, naproxen, heparin, Fibrinolytika and non-steroidal anti-inflammatory drugs. The combination with acetylsalicylic acid and vitamin K antagonist (warfarin, Dicoumarol) is particularly dangerous.

Proton pump inhibitors that are used against excessive stomach acid, inhibit conversion of clopidogrel to its active form of action in the body. Thus, Clopidogrel can have its desired effect only inadequately. According to the current state of knowledge, the doctor should avoid the combination of clopidogrel and a Proton pump inhibitor. For example, the H2 blockers ranitidine (but not cimetidine!) could serve as Ausweichmittel to the blockade of the gastric acid. If it is still necessary to use a Proton pump inhibitor, the doctor of pantoprazole should choose.

Contra-indications

The following information about contra-indications in the application of clopidogrel in General, pregnancy & lactation, and in children. It is important to note that the contra-indications can be different depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

When should Clopidogrel be used?

Clopidogrel may not be included in

  • Hypersensitivity to the active substance
  • severe hepatic impairment
  • existing bleeding
  • Condition immediately after a heart attack or stroke.

Only after risk benefit by a doctor and under its control, the active substance must be taken in renal impairment as well as an increased risk of bleeding, blood coagulation and coagulation retardant agents (warfarin, coumarins) taking. Note: Before an operation Clopidogrel must be removed often. It is worth noting that the effect only seven days later subsides.

What must you consider when pregnancy and breast-feeding?

There is still no adequate studies whether Clopidogrel deals damage to the unborn child. In animal studies, but so far no damage to the unborn was detected. It is still unknown whether the medicinal product in the human breast milk passes. In tests on rats, but, Clopidogrel was detected in breast milk.

Therefore, no use of clopidogrel should be done during pregnancy or breast-feeding. As a security precaution should be breastfed off during a treatment with the drug.

What is taken into account in children?

For children and young people under 18, the safety and efficacy of clopidogrel were not investigated. Therefore, should be given the drug as a precaution only adults and must not be used in this age range.

What side effects can Clopidogrel have?

Below, you will learn the most important thing possible, well-known side effects of clopidogrel. These side effects should not occur, but can. Because everyone reacts differently to medications. Please also note that the side effects in type and frequency can vary depending on the pharmaceutical form of a drug (for example, Tablet, syringe, ointment).

Common side effects: bleeding; Skin bleeding; Nose bleeds; Bruising; Bruises; Cerebral bleeding; Digestive disorders; Abdominal pain; Diarrhea.

Uncommon side effects: nausea and vomiting; Magenschleimhautentzündungen; Bloating; Constipation; Stomach and duodenal ulcers; Rash; Itching; Headache; Drowsiness; Errors of touch.

Rare side effects: dizziness.

Very rare and occasional side effects: disturbances of blood formation; severe allergic reactions; Confusion; Delusions; Drop in blood pressure; Taste disorders; Arthritis; Seizures of the respiratory muscles; Pneumonia; Intestinal inflammation; Pancreatitis; Inflammation of the mucous membrane of the mouth; Liver dysfunction; Biliary dysfunction; Inflammation; Liver failure; Disorders of the skin; Swelling of the skin; Redness; Itching skin; Disorders of the locomotor system; Connective tissue disorders; Bone disease; Joint pain; Muscle pain; Renal impairment; Nephritis; Fever, serum creatinine rise.

Specialties: In combination with acetylsalicylic acid light and heavy bleeding (especially in the gastro intestinal tract) occur much more frequently. Life-threatening or even fatal bleeding and haemorrhage not increasing, however, the combination.

When treated with Clopidogrel occurred in some cases two to three months after the start of therapy extensive bruising and bleeding in the muscles. This is probably to reduce the concentration of factor VIII. Large bruises occur during treatment with clopidogrel, the doctor should examine blood clotting.

Negative impact on liver function have been shown when treated with Clopidogrel it. Signs of liver damage on (gain weight by water retention in the abdominal cavity, itching, nausea, confusion, or jaundice) during treatment with the drug a doctor is immediately to communicate.

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